CFHR1 · rs3753394
Where this position leads
Condition: Complement C3 and C4 Levels
What the study found
Who was studied 1,999 Han Chinese ancestry male individuals; replicated in 1,496 Han Chinese ancestry male individuals.
The effect Each copy of the C allele shifted the measure 0.05 g/L lower (95% confidence interval 0.030-0.070); p = 7 × 10−11.
How common The C allele had a frequency of about 43% in the people studied.
Where it sits Chromosome 1, band 1q31.3 — in a regulatory region of CFH.
What ClinVar records
Classification
Benign for CFH-related disorder; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2021-05-10.
ClinVar record 1249325 NC_000001.11:g.196651787C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs3753394 is a single position in the genome, in or near the CFHR1 gene. Published research associates it with complement c3 and c4 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Complement C3 and C4 Levels. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, PLoS Genet 2012, PMID:23028341. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Complement C3 and C4 levels (rs3753394). MyGeneLog™. https://www.mygenelog.com/variants/rs3753394