Standard

Hemoglobin levels

TMEM116 · rs3752630

Where this position leads

Condition: Blood Cell Counts

rs3752630 Condition: Blood Cell Counts Blood Cell Counts Condition rs3752630 rs3752630 TMEM116

What the study found

Who was studied 684,122 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.042 lower; p = 2 × 10−53.

Where it sits Chromosome 12, band 12q24.13 — a missense change in TMEM116.

What each result means

A/A No copy of the version the research linked to Hemoglobin levels. This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to Hemoglobin levels. That is a smaller link than two copies.
C/C Two copies of the version the research linked to Hemoglobin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs3752630

What is rs3752630?

rs3752630 is a single position in the genome, in or near the TMEM116 gene. Published research associates it with hemoglobin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3752630 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs3752630 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3752630 come from?

GWAS Catalog, Communications biology 2020, PMID:32327693. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Hemoglobin levels (rs3752630). MyGeneLog™. https://www.mygenelog.com/variants/rs3752630

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