Sensitive

Type 2 diabetes

KLHDC5 · rs3751237

Where this position leads

Condition: Type 2 Diabetes

rs3751237 Condition: Type 2 Diabetes Type 2 Diabetes Condition rs3751237 rs3751237 KLHDC5

What the study found

Who was studied 36,614 Japanese ancestry cases, 155,150 Japanese ancestry controls.

The effect The reported allele is T; the catalogue records no effect size ; p = 7 × 10−14.

How common The T allele had a frequency of about 69% in the people studied.

Where it sits Chromosome 12, band 12p11.22 — between genes, 4.2 kb from RN7SKP15.

What each result means

G/G No copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs3751237

What is rs3751237?

rs3751237 is a single position in the genome, in or near the KLHDC5 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3751237 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs3751237 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3751237 come from?

GWAS Catalog, Nature genetics 2019, PMID:30718926. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes (rs3751237). MyGeneLog™. https://www.mygenelog.com/variants/rs3751237

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