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Who was studied 14,034 European ancestry cases, 91,214 European ancestry controls.
The effect
Each copy of the T allele carried 1.47 times the odds of Early age-related macular degeneration (95% confidence interval 1.44-1.5); p = 1 × 10−116.
How common The T allele had a frequency of about 22% in the people studied.
Where it sits Chromosome 10, band 10q26.13 — in an intron of ARMS2.
What ClinVar records
Classificationnot provided; no classification provided (0 of 4 stars, 1 submitter).
ClinVar record 162171NM_001099667.3(ARMS2):c.297+881C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to Early age-related macular degeneration. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Early age-related macular degeneration. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Early age-related macular degeneration. That is the strongest link of the three results. A link in a study is not a diagnosis.
BMC medical genomics · 2020 · PMID 32843070 · open access
Questions about rs3750847
What is rs3750847?
rs3750847 is a single position in the genome, in or near the ARMS2 gene. Published research associates it with early age-related macular degeneration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3750847 linked to?
On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.
Does having rs3750847 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3750847 come from?
GWAS Catalog, BMC medical genomics 2020, PMID:32843070. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 1722112Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others12Total17Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Early age-related macular degeneration (rs3750847). MyGeneLog™. https://www.mygenelog.com/variants/rs3750847