Ossification of the posterior longitudinal ligament of the spine
RSPO2 · rs374810
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 1,112 Japanese ancestry cases, 6,810 Japanese ancestry controls; replicated in 548 Japanese ancestry cases, 6,469 Japanese ancestry controls.
The effect
Each copy of the G allele carried 1.34 times the odds of Ossification of the posterior longitudinal ligament of the spine (95% confidence interval 1.24-1.44); p = 2 × 10−13.
How common The G allele had a frequency of about 61% in the people studied.
Where it sits Chromosome 8, band 8q23.1 — between genes, 0 kb from RSPO2.
What each result means
A/ANo copy of the version the research linked to Ossification of the posterior longitudinal ligament of the spine. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Ossification of the posterior longitudinal ligament of the spine. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Ossification of the posterior longitudinal ligament of the spine. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs374810 is a single position in the genome, in or near the RSPO2 gene. Published research associates it with ossification of the posterior longitudinal ligament of the spine. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs374810 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs374810 come from?
GWAS Catalog, Nat Genet 2014, PMID:25064007. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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Ossification of the posterior longitudinal ligament of the spine (rs374810). MyGeneLog™. https://www.mygenelog.com/variants/rs374810