0 342118124213Reads by AI crawlersClaude0ChatGPT2Google · Gemini1Perplexity1Meta AI8Microsoft · Copilot1Amazon2Apple4China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others13Total34Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 4,110 European ancestry cases, 13,569 European ancestry controls; replicated in 1,098 European ancestry cases, 498 ,016 European ancestry controls.
The effect
Each copy of the A allele carried 1.15 times the odds of Creutzfeldt-Jakob disease (sporadic) (95% confidence interval 1·04–1·28); p = 1 × 10−10.
How common The A allele had a frequency of about 41% in the people studied.
Where it sits Chromosome 1, band 1q25.3 — a synonymous change in STX6.
What each result means
A/ATwo copies of the version the research linked to Creutzfeldt-Jakob disease (sporadic). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Creutzfeldt-Jakob disease (sporadic). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Creutzfeldt-Jakob disease (sporadic). This is the starting point the study compared everyone against.
rs3747957 is a single position in the genome, in or near the STX6 gene. Published research associates it with creutzfeldt-jakob disease (sporadic). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3747957 linked to?
On MyGeneLog this position is linked to Sporadic Creutzfeldt-Jakob Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs3747957 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3747957 come from?
GWAS Catalog, Lancet Neurol 2020, PMID:32949544. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 342118124213Reads by AI crawlersClaude0ChatGPT2Google · Gemini1Perplexity1Meta AI8Microsoft · Copilot1Amazon2Apple4China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others13Total34Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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