1 4632328223120Reads by AI crawlersClaude3ChatGPT2Google · Gemini3Perplexity2Meta AI8Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others20Total46Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,999 Han Chinese ancestry male individuals; replicated in 1,496 Han Chinese ancestry male individuals.
The effect
Each copy of the T allele shifted the measure 0.09 g/L higher (95% confidence interval 0.070-0.110); p = 2 × 10−9.
How common The T allele had a frequency of about 6% in the people studied.
Where it sits Chromosome 19, band 19p13.3 — in an intron of C3.
What ClinVar records
ClassificationBenign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2021-06-18.
ClinVar record 1226583NM_000064.4(C3):c.3391-33G>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to Complement C3 and C4 levels. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Complement C3 and C4 levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Complement C3 and C4 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
PLoS genetics · 2012 · PMID 23028341 · open access
Questions about rs3745567
What is rs3745567?
rs3745567 is a single position in the genome, in or near the C3 gene. Published research associates it with complement c3 and c4 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3745567 linked to?
On MyGeneLog this position is linked to Complement C3 and C4 Levels. The research behind each link, and its sources, are set out on that condition page.
Does having rs3745567 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3745567 come from?
GWAS Catalog, PLoS Genet 2012, PMID:23028341. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 4632328223120Reads by AI crawlersClaude3ChatGPT2Google · Gemini3Perplexity2Meta AI8Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others20Total46Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Complement C3 and C4 levels (rs3745567). MyGeneLog™. https://www.mygenelog.com/variants/rs3745567