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Who was studied 1,840 European ancestry cases, 5,163 European ancestry controls and (Liu et al); replicated in 620 European ancestry cases, 2,514 European ancestry controls.
The effect
Each copy of the A allele carried 1.38 times the odds of Primary biliary cholangitis (95% confidence interval 1.32-1.44); p = 2 × 10−13.
How common The A allele had a frequency of about 23% in the people studied.
Where it sits Chromosome 19, band 19q13.33 — in an intron of SPIB.
What each result means
A/ATwo copies of the version the research linked to Primary biliary cholangitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Primary biliary cholangitis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Primary biliary cholangitis. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs3745516
What is rs3745516?
rs3745516 is a single position in the genome, in or near the SPIB gene. Published research associates it with primary biliary cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3745516 linked to?
On MyGeneLog this position is linked to Primary Biliary Cholangitis. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs3745516?
Subjects that appear in the title or abstract of the same papers as this rsID include liver (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs3745516 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3745516 come from?
GWAS Catalog, Nat Genet 2011, PMID:21399635. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
3 5252334223325Reads by AI crawlersClaude5ChatGPT2Google · Gemini3Perplexity3Meta AI4Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)3ByteDance (Doubao)3Others25Total52Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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