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Primary biliary cholangitis

SPIB · rs3745516

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Primary biliary cholangitis compared to the general population. (GWAS Catalog, Nat Genet 2011, PMID:21399635)

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Primary biliary cholangitis. (GWAS Catalog, Nat Genet 2011, PMID:21399635)

G/G Published research associates this genotype with typical/baseline likelihood of Primary biliary cholangitis — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2011, PMID:21399635)

Source: GWAS Catalog, Nat Genet 2011, PMID:21399635

Questions about rs3745516

What is rs3745516?

rs3745516 is a single position in the genome, in or near the SPIB gene. Published research associates it with primary biliary cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs3745516 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3745516 come from?

GWAS Catalog, Nat Genet 2011, PMID:21399635. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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