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Who was studied 400 European ancestry cases, 6,101 European ancestry controls; replicated in 346 European ancestry cases, 1,609 European ancestry controls.
The effect
Each copy of the T allele carried 1.60 times the odds of Kawasaki disease (95% confidence interval 1.4-1.9); p = 1 × 10−9.
How common The T allele had a frequency of about 13% in the people studied.
Where it sits Chromosome 19, band 19q13.2 — in the 3′ untranslated region of ACTMAP.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Kawasaki disease — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Kawasaki disease.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Kawasaki disease compared to the general population.
European journal of human genetics : EJHG · 2021 · PMID 33772158 · open access
Questions about rs3745213
What is rs3745213?
rs3745213 is a single position in the genome, in or near the ITPKC gene. Published research associates it with kawasaki disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3745213 linked to?
On MyGeneLog this position is linked to Kawasaki Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs3745213 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3745213 come from?
GWAS Catalog, Eur J Hum Genet 2021, PMID:33772158. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
4 341213712215Reads by AI crawlersClaude1ChatGPT2Google · Gemini1Perplexity3Meta AI7Microsoft · Copilot1Amazon2Apple2Others15Total34Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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