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Who was studied 365,998 European ancestry individuals, 63,490 African ancestry individuals, 22,802 Hispanic individuals, 4,792 Asian ancestry individuals, 2,695 Native American ancestry individuals; replicated in 299,024 European ancestry individuals, 17,277 individuals.
The effect
Each copy of the A allele shifted the measure 0.276 mmHg lower (95% confidence interval 0.2-0.35); p = 1 × 10−13.
How common The A allele had a frequency of about 29% in the people studied.
Where it sits Chromosome 17, band 17q25.1 — in an intron of UNC13D.
What ClinVar records
ClassificationBenign for Familial hemophagocytic lymphohistiocytosis 3, Autoinflammatory syndrome; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2026-01-26.
ClinVar record 1166947NM_199242.3(UNC13D):c.117+59C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to Systolic blood pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Systolic blood pressure. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Systolic blood pressure. This is the starting point the study compared everyone against.
Nature genetics · 2019 · PMID 30578418 · open access
Questions about rs3744010
What is rs3744010?
rs3744010 is a single position in the genome, in or near the UNC13D gene. Published research associates it with systolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3744010 linked to?
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
Does having rs3744010 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3744010 come from?
GWAS Catalog, Nature genetics 2019, PMID:30578418. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 211122213Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others13Total21Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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