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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 9,714 European ancestry cases, 48,471 European ancestry controls; replicated in 1,977 European ancestry cases, 17,627 European ancestry controls.
The effect
Each copy of the G allele carried 1.11 times the odds of Chronic sputum production (95% confidence interval 1.08-1.15); p = 1 × 10−10.
How common The G allele had a frequency of about 57% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — in an intron of HLA-DRB5.
What each result means
C/CNo copy of the version the research linked to Chronic sputum production. This is the starting point the study compared everyone against.
C/GOne copy of the version the research linked to Chronic sputum production. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Chronic sputum production. That is the strongest link of the three results. A link in a study is not a diagnosis.
The European respiratory journal · 2023 · PMID 37263751 · open access
Questions about rs374248993
What is rs374248993?
rs374248993 is a single position in the genome, in or near the HLA-DRB5 gene. Published research associates it with chronic sputum production. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs374248993 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs374248993 come from?
GWAS Catalog, The European respiratory journal 2023, PMID:37263751. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Chronic sputum production (rs374248993). MyGeneLog™. https://www.mygenelog.com/variants/rs374248993