Neuroticism
NOS1 · rs3741475
Where this position leads
Condition: Neuroticism
What the study found
Who was studied 449,484 European ancestry individuals.
The effect Each copy of the A allele shifted the measure 6.37 z score higher (95% confidence interval -); p = 2 × 10−10.
Where it sits Chromosome 12, band 12q24.22 — a synonymous change in NOS1.
What ClinVar records
Classification
Benign for NOS1-related disorder; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2019-10-17.
ClinVar record 3061017 NM_000620.5(NOS1):c.3258C>T (p.Asp1086=)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
From our blog
Questions about rs3741475
What is rs3741475?
rs3741475 is a single position in the genome, in or near the NOS1 gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3741475 linked to?
On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs3741475?
Subjects that appear in the title or abstract of the same papers as this rsID include brain and memory (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs3741475 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3741475 come from?
GWAS Catalog, Nat Genet 2018, PMID:29942085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
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Neuroticism (rs3741475). MyGeneLog™. https://www.mygenelog.com/variants/rs3741475