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Body mass index and HDL-C (pairwise)

INHBC · rs3741414

Where this position leads

Condition: Obesity and Body Weight

rs3741414 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs3741414 rs3741414 INHBC

What the study found

Who was studied 509,429 European ancestry individuals, 16,962 East Asian, South Asian, Hispanic and African American ancestry individuals.

The effect The reported allele is T; the catalogue records no effect size ; p = 2 × 10−13.

How common The T allele had a frequency of about 19% in the people studied.

Where it sits Chromosome 12, band 12q13.3 — in the 3′ untranslated region of INHBC.

What each result means

C/C No copy of the version the research linked to Body mass index and HDL-C (pairwise). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Body mass index and HDL-C (pairwise). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Body mass index and HDL-C (pairwise). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs3741414

What is rs3741414?

rs3741414 is a single position in the genome, in or near the INHBC gene. Published research associates it with body mass index and hdl-c (pairwise). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3741414 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs3741414 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3741414 come from?

GWAS Catalog, Nat Metab 2021, PMID:33619380. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Body mass index and HDL-C (pairwise) (rs3741414). MyGeneLog™. https://www.mygenelog.com/variants/rs3741414

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