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Who was studied 18,719 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern cases, 2,441,938 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern controls.
The effect
Each copy of the T allele shifted the measure 1.28 higher (95% confidence interval 0.85-1.71); p = 6 × 10−9.
How common The T allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 1, band 1p22.1 — between genes, 19.6 kb from BRDT.
What each result means
C/CNo copy of the version the research linked to Graves' disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Graves' disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Graves' disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 41644669 · open access
Questions about rs374005375
What is rs374005375?
rs374005375 is a single position in the genome, in or near the near BRDT gene. Published research associates it with graves' disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs374005375 linked to?
On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs374005375 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs374005375 come from?
GWAS Catalog, Nature genetics 2026, PMID:41644669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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