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Self-reported math ability

CUL3 · rs3738952

Where this position leads

What the study found

Who was studied 564,698 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0262 higher (95% confidence interval 0.02-0.033); p = 1 × 10⁻¹⁴.

How common The C allele had a frequency of about 91% in the people studied.

Where it sits Chromosome 2, band 2q36.2 — a missense change in CUL3.

What ClinVar records

Classification Benign for Pseudohypoaldosteronism type 2E; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 7 submitters), last evaluated 2026-02-03. ClinVar record 259091 NM_003590.5(CUL3):c.1699G>A (p.Val567Ile)

What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Self-reported math ability compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Self-reported math ability.

T/T Published research associates this genotype with typical/baseline likelihood of Self-reported math ability — no copies of the reported risk allele.

Source

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

Lee JJ, Wedow R, Okbay A, Kong E, Maghzian O, Zacher M, Nguyen-Viet TA, Bowers P, Sidorenko J, Karlsson Linnér R, Fontana MA, Kundu T

and 65 more — show all

23andMe Research Team · COGENT (Cognitive Genomics Consortium) · Social Science Genetic Association Consortium

Nature genetics · 2018 · PMID 30038396

Questions about rs3738952

What is rs3738952?

rs3738952 is a single position in the genome, in or near the CUL3 gene. Published research associates it with self-reported math ability. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3738952 linked to?

On MyGeneLog this position is linked to Educational Attainment. The research behind each link, and its sources, are set out on that condition page.

Does having rs3738952 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3738952 come from?

GWAS Catalog, Nat Genet 2018, PMID:30038396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Self-reported math ability (rs3738952). MyGeneLog™. https://www.mygenelog.com/variants/rs3738952

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