Who was studied 63,608 European ancestry drinkers, 10,193 African American or Afro-Caribbean heavy drinkers, 2,441 Asian ancestry drinkers, 5,084 Hispanic or Latin American drinkers, 27,494 European ancestry non-drinkers, 11,224 African American or Afro-Caribbean non-drinkers, 9,924 Asian ancestry non-drinkers, 3,387 Hispanic or Latin American non-drinkers; replicated in 238,002 European ancestry drinkers, 2,280 African American drinkers, 54,081 Asian ancestry drinkers, 6,452 Hispanic drinkers, 43,316 European ancestry non-drinkers, 2,761 African American non-drinkers, 86,945 Asian ancestry non-drinkers, 6,925 Hispanic non-drinkers.
The effect
The reported allele is A; the catalogue records no effect size
; p = 2 × 10−10.
How common The A allele had a frequency of about 52% in the people studied.
Where it sits Chromosome 8, band 8p23.1 — in an intron of GATA4.
What ClinVar records
ClassificationBenign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-09-04.
ClinVar record 1298187NM_001308093.3(GATA4):c.787-224G>A
What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Systolic blood pressure x alcohol consumption interaction (2df test) compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Systolic blood pressure x alcohol consumption interaction (2df test).
G/GPublished research associates this genotype with typical/baseline likelihood of Systolic blood pressure x alcohol consumption interaction (2df test) — no copies of the reported risk allele.
rs3735814 is a single position in the genome, in or near the GATA4 gene. Published research associates it with systolic blood pressure x alcohol consumption interaction (2df test). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3735814 linked to?
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
Does having rs3735814 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3735814 come from?
GWAS Catalog, PLoS One 2018, PMID:29912962. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0
17
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.