CDKN2A · rs3731239
Where this position leads
Condition: Coronary Artery Disease
What the study found
Who was studied at least 185,000 European or East Asian ancestry individuals (MTAG boosted by 455,258 Alzheimer's disease samples).
The effect Each copy of the G allele shifted the measure 0.0261 lower (95% confidence interval 0.02-0.033); p = 2 × 10−15.
Where it sits Chromosome 9, band 9p21.3 — in an intron of CDKN2A.
What ClinVar records
Classification
Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2019-01-10.
ClinVar record 1241937 NM_000077.5(CDKN2A):c.150+459T>C
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs3731239 is a single position in the genome, in or near the CDKN2A gene. Published research associates it with coronary artery disease (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2024, PMID:39537608. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Coronary artery disease (MTAG) (rs3731239). MyGeneLog™. https://www.mygenelog.com/variants/rs3731239