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Who was studied 10,906 European ancestry cases, 366,221 European ancestry controls.
The effect
Each copy of the T allele carried 1.23 times the odds of Multiple myeloma (95% confidence interval 1.2-1.3); p = 3 × 10−16.
How common The T allele had a frequency of about 85% in the people studied.
Where it sits Chromosome 9, band 9p21.3 — in an intron of CDKN2A.
What each result means
C/CNo copy of the version the research linked to Multiple myeloma. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Multiple myeloma. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Multiple myeloma. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2024 · PMID 39103364 · open access
Questions about rs3731222
What is rs3731222?
rs3731222 is a single position in the genome, in or near the CDKN2A gene. Published research associates it with multiple myeloma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3731222 linked to?
On MyGeneLog this position is linked to Multiple Myeloma. The research behind each link, and its sources, are set out on that condition page.
Does having rs3731222 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3731222 come from?
GWAS Catalog, Nature communications 2024, PMID:39103364. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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