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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 125,000 African ancestry individuals (MTAG boosted by high-density lipoprotein and triglyceride samples).
The effect
Each copy of the G allele shifted the measure 0.0507 higher (95% confidence interval 0.042-0.06); p = 1 × 10−28.
Where it sits Chromosome 16, band 16q22.1 — in an intron of E2F4.
What each result means
G/GTwo copies of the version the research linked to Total cholesterol levels (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Total cholesterol levels (MTAG). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Total cholesterol levels (MTAG). This is the starting point the study compared everyone against.
Nature communications · 2023 · PMID 37669986 · open access
Questions about rs3730403
What is rs3730403?
rs3730403 is a single position in the genome, in or near the E2F4 gene. Published research associates it with total cholesterol levels (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs3730403 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3730403 come from?
GWAS Catalog, Nature communications 2023, PMID:37669986. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Total cholesterol levels (MTAG) (rs3730403). MyGeneLog™. https://www.mygenelog.com/variants/rs3730403