Sensitive

Pancreatic cancer

BACH1 · rs372883

Where this position leads

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹³, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 981 Han Chinese ancestry cases, 1,991 Han Chinese ancestry controls; replicated in 2,603 Han Chinese ancestry cases, 2,877 Han Chinese ancestry controls.

The effect Each copy of the T allele carried 1.27 times the odds of Pancreatic cancer (95% confidence interval 1.19-1.33); p = 2 × 10⁻¹³.

Where it sits Chromosome 21, band 21q21.3 — in the 3′ untranslated region of BACH1.

How common each version is

CT

Korean KRGDB

C 42.4% · T 57.6%

Korean Korea4K

C 42.4% · T 57.6%

Korean Korea1K

C 41.3% · T 58.7%

Japanese ToMMo

C 43.2% · T 56.8%

Vietnamese

C 47.7% · T 52.3%

World gnomAD

C 52.7% · T 47.3%

World 1000 Genomes

C 57.2% · T 42.8%

World TOPMed

C 53.3% · T 46.7%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to Pancreatic cancer. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Pancreatic cancer. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Pancreatic cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations

Wu C, Miao X, Huang L, Che X, Jiang G, Yu D, Yang X, Cao G, Hu Z, Zhou Y, Zuo C, Wang C

and 26 more — show all

Zhang X, Zhou Y, Yu X, Dai W, Li Z, Shen H, Liu L, Chen Y, Zhang S, Wang X, Zhai K, Chang J, Liu Y, Sun M, Cao W, Gao J, Ma Y, Zheng X, Cheung ST, Jia Y, Xu J, Tan W, Zhao P, Wu T, Wang C, Lin D

Nature genetics · 2011 · PMID 22158540

Questions about rs372883

What is rs372883?

rs372883 is a single position in the genome, in or near the BACH1 gene. Published research associates it with pancreatic cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs372883 linked to?

On MyGeneLog this position is linked to Pancreatic Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs372883 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs372883 come from?

GWAS Catalog, Nat Genet 2011, PMID:22158540. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pancreatic cancer (rs372883). MyGeneLog™. https://www.mygenelog.com/variants/rs372883

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