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Chronotype

FBXL13 · rs372229746

Where this position leads

Condition: Sleep and Circadian Rhythm

rs372229746 Condition: Sleep and Circadian Rhythm Sleep and Circadian Rhythm Condition rs372229746 rs372229746 FBXL13

What the study found

Who was studied 100,420 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.034 higher (95% confidence interval 0.025-0.045); p = 5 × 10−10.

How common The A allele had a frequency of about 45% in the people studied.

Where it sits Chromosome 7, band 7q22.1 — between genes, 0.6 kb from RASA4B.

What each result means

A/A Two copies of the version the research linked to Chronotype. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Chronotype. That is a smaller link than two copies.
G/G No copy of the version the research linked to Chronotype. This is the starting point the study compared everyone against.
Source
Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank
Lane JM, Vlasac I, Anderson SG, Kyle SD, Dixon WG, Bechtold DA, Gill S, Little MA, Luik A, Loudon A, Emsley R, Scheer FA
and 6 more — show all
Scheer FA, Lawlor DA, Redline S, Ray DW, Rutter MK, Saxena R
Nature communications · 2016 · PMID 26955885 · open access

Questions about rs372229746

What is rs372229746?

rs372229746 is a single position in the genome, in or near the FBXL13 gene. Published research associates it with chronotype. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs372229746 linked to?

On MyGeneLog this position is linked to Sleep and Circadian Rhythm. The research behind each link, and its sources, are set out on that condition page.

Does having rs372229746 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs372229746 come from?

GWAS Catalog, Nat Commun 2016, PMID:26955885. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Chronotype (rs372229746). MyGeneLog™. https://www.mygenelog.com/variants/rs372229746

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