Gene Knowledge Graph
UTC
Standard

Chronotype

near NFKB1 · rs371681307

Where this position leads

Condition: Sleep and Circadian Rhythm

rs371681307 Condition: Sleep and Circadian Rhythm Sleep and Circadian Rhythm Condition rs371681307 rs371681307 near NFKB1

What the study found

Who was studied 101,185 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.062 lower (95% confidence interval 0.04-0.084); p = 4 × 10−8.

How common The T allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 4, band 4q24 — in an intron of LOC105377347.

What each result means

C/C No copy of the version the research linked to Chronotype. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Chronotype. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Chronotype. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits
Hammerschlag AR, Stringer S, de Leeuw CA, Sniekers S, Taskesen E, Watanabe K, Blanken TF, Dekker K, Te Lindert BHW, Wassing R, Jonsdottir I, Thorleifsson G
and 10 more — show all
Stefansson H, Gislason T, Berger K, Schormair B, Wellmann J, Winkelmann J, Stefansson K, Oexle K, Van Someren EJW, Posthuma D
Nature genetics · 2017 · PMID 28604731 · open access

Questions about rs371681307

What is rs371681307?

rs371681307 is a single position in the genome, in or near the near NFKB1 gene. Published research associates it with chronotype. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs371681307 linked to?

On MyGeneLog this position is linked to Sleep and Circadian Rhythm. The research behind each link, and its sources, are set out on that condition page.

Does having rs371681307 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs371681307 come from?

GWAS Catalog, Nat Genet 2017, PMID:28604731. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Chronotype (rs371681307). MyGeneLog™. https://www.mygenelog.com/variants/rs371681307

← See all variants