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Total concentration of branched-chain amino acids (leucine + isoleucine + valine)

CLEC18C · rs370014171

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs370014171 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition rs370014171 rs370014171 CLEC18C

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the C allele shifted the measure 0.09 mmol/L lower (95% confidence interval 0.09-0.09); p = 1 × 10−175.

Where it sits Chromosome 16, band 16q22.1 — in the 5′ untranslated region of CLEC18C.

What each result means

C/C Two copies of the version the research linked to Total concentration of branched-chain amino acids (leucine + isoleucine + valine). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Total concentration of branched-chain amino acids (leucine + isoleucine + valine). That is a smaller link than two copies.
G/G No copy of the version the research linked to Total concentration of branched-chain amino acids (leucine + isoleucine + valine). This is the starting point the study compared everyone against.
Source

Questions about rs370014171

What is rs370014171?

rs370014171 is a single position in the genome, in or near the CLEC18C gene. Published research associates it with total concentration of branched-chain amino acids (leucine + isoleucine + valine). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs370014171 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs370014171 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs370014171 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Total concentration of branched-chain amino acids (leucine + isoleucine + valine) (rs370014171). MyGeneLog™. https://www.mygenelog.com/variants/rs370014171

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