MC1R · rs368507952
Where this position leads
Condition: Hair Color
What the study found
Who was studied 15,731 British ancestry red hair individuals, 283,920 British ancestry brown or black hair individuals.
The effect The reported allele is A; the catalogue records no effect size ; p = 2 × 10−93.
How common The A allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 16, band 16q24.3 — a missense change in MC1R.
What ClinVar records
Classification
Conflicting classifications of pathogenicity for Melanoma, cutaneous malignant, susceptibility to, 5, Tyrosinase-positive oculocutaneous albinism; criteria provided, conflicting classifications (1 of 4 stars, 3 submitters), last evaluated 2025-09-22.
ClinVar record 470716 NM_002386.4(MC1R):c.917G>A (p.Arg306His)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs368507952 is a single position in the genome, in or near the MC1R gene. Published research associates it with red vs. brown/black hair color. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Hair Color. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2018, PMID:30531825. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Red vs. brown/black hair color (rs368507952). MyGeneLog™. https://www.mygenelog.com/variants/rs368507952