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Hematocrit

SBF2 · rs368417629

Where this position leads

Conditions: Blood Cell Counts, Colon Polyp

rs368417629 Condition: Blood Cell Counts Blood Cell Counts Condition Condition: Colon Polyp Colon Polyp Condition rs368417629 rs368417629 SBF2

What the study found

Who was studied 350,475 European ancestry individuals, 153,015 East Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0328 lower (95% confidence interval 0.029-0.037); p = 4 × 10−58.

Where it sits Chromosome 11, band 11p15.4 — in an intron of SBF2.

What each result means

G/G Published research associates this genotype with typical/baseline likelihood of Hematocrit — no copies of the reported risk allele.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hematocrit.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hematocrit compared to the general population.
Source
A cross-population atlas of genetic associations for 220 human phenotypes
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A
and 34 more — show all
Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y
FinnGen
Nature genetics · 2021 · PMID 34594039

Questions about rs368417629

What is rs368417629?

rs368417629 is a single position in the genome, in or near the SBF2 gene. Published research associates it with hematocrit. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs368417629 linked to?

On MyGeneLog this position is linked to Blood Cell Counts, Colon Polyp. The research behind each link, and its sources, are set out on that condition page.

Does having rs368417629 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs368417629 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Hematocrit (rs368417629). MyGeneLog™. https://www.mygenelog.com/variants/rs368417629

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