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Psoriasis

PRM3 · rs367569

Where this position leads

Condition: Psoriasis

rs367569 Condition: Psoriasis Psoriasis Condition rs367569 rs367569 PRM3

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Psoriasis compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Psoriasis.
T/T Published research associates this genotype with typical/baseline likelihood of Psoriasis — no copies of the reported risk allele.
Source
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, Kang HM, Allen MH
and 53 more — show all
McManus R, Novelli G, Samuelsson L, Schalkwijk J, Ståhle M, Burden AD, Smith CH, Cork MJ, Estivill X, Bowcock AM, Krueger GG, Weger W, Worthington J, Tazi-Ahnini R, Nestle FO, Hayday A, Hoffmann P, Winkelmann J, Wijmenga C, Langford C, Edkins S, Andrews R, Blackburn H, Strange A, Band G, Pearson RD, Vukcevic D, Spencer CC, Deloukas P, Mrowietz U, Schreiber S, Weidinger S, Koks S, Kingo K, Esko T, Metspalu A, Lim HW, Voorhees JJ, Weichenthal M, Wichmann HE, Chandran V, Rosen CF, Rahman P, Gladman DD, Griffiths CE, Reis A, Kere J, Nair RP, Franke A, Barker JN, Abecasis GR, Elder JT, Trembath RC
Collaborative Association Study of Psoriasis (CASP) · Genetic Analysis of Psoriasis Consortium · Psoriasis Association Genetics Extension · Wellcome Trust Case Control Consortium 2
Nature genetics · 2012 · PMID 23143594 · open access

Questions about rs367569

What is rs367569?

rs367569 is a single position in the genome, in or near the PRM3 gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs367569 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs367569 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs367569 come from?

GWAS Catalog, Nat Genet 2012, PMID:23143594. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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