Sensitive

Restless legs syndrome

MYT1 · rs365032

Where this position leads

Condition: Restless Legs Syndrome

rs365032 Condition: Restless Legs Syndrome Restless Legs Syndrome Condition rs365032 rs365032 MYT1

What the study found

Who was studied 15,126 European ancestry cases, 95,725 European ancestry controls; replicated in 30,770 European ancestry cases, 286,913 European ancestry controls.

The effect Each copy of the G allele carried 1.13 times the odds of Restless legs syndrome (95% confidence interval 1.11-1.15); p = 2 × 10−34.

How common The G allele had a frequency of about 27% in the people studied.

Where it sits Chromosome 20, band 20q13.33 — in an intron of MYT1.

What each result means

A/A No copy of the version the research linked to Restless legs syndrome. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Restless legs syndrome. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Restless legs syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs365032

What is rs365032?

rs365032 is a single position in the genome, in or near the MYT1 gene. Published research associates it with restless legs syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs365032 linked to?

On MyGeneLog this position is linked to Restless Legs Syndrome. The research behind each link, and its sources, are set out on that condition page.

Does having rs365032 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs365032 come from?

GWAS Catalog, Lancet Neurol 2017, PMID:29029846. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Restless legs syndrome (rs365032). MyGeneLog™. https://www.mygenelog.com/variants/rs365032

← See all variants