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Noncognitive aspects of educational attainment

HTT · rs363096

Where this position leads

What the study found

Who was studied 510,795 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0509 lower (95% confidence interval 0.037-0.065); p = 1 × 10⁻¹².

How common The T allele had a frequency of about 41% in the people studied.

Where it sits Chromosome 4, band 4p16.3 — at a splice region of HTT.

What ClinVar records

Classification Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2026-02-02. ClinVar record 1598953 NM_001388492.1(HTT):c.4464-4T>C

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C No copy of the version the research linked to Noncognitive aspects of educational attainment. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Noncognitive aspects of educational attainment. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Noncognitive aspects of educational attainment. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction

Demange PA, Malanchini M, Mallard TT, Biroli P, Cox SR, Grotzinger AD, Tucker-Drob EM, Abdellaoui A, Arseneault L, van Bergen E, Boomsma DI, Caspi A

and 15 more — show all

Corcoran DL, Domingue BW, Harris KM, Ip HF, Mitchell C, Moffitt TE, Poulton R, Prinz JA, Sugden K, Wertz J, Williams BS, de Zeeuw EL, Belsky DW, Harden KP, Nivard MG

Nature genetics · 2021 · PMID 33414549 · open access

Questions about rs363096

What is rs363096?

rs363096 is a single position in the genome, in or near the HTT gene. Published research associates it with noncognitive aspects of educational attainment. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs363096 linked to?

On MyGeneLog this position is linked to Educational Attainment. The research behind each link, and its sources, are set out on that condition page.

Does having rs363096 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs363096 come from?

GWAS Catalog, Nature genetics 2021, PMID:33414549. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Noncognitive aspects of educational attainment (rs363096). MyGeneLog™. https://www.mygenelog.com/variants/rs363096

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