Sensitive

Crohn's disease

near TNF · rs361525

Where this position leads

What the study found

Who was studied 10,760 European ancestry female cases, 22,345 European ancestry female controls.

The effect Each copy of the A allele carried 1.26 times the odds of Crohn's disease (95% confidence interval 1.171-1.35); p = 3 × 10⁻¹⁰.

Where it sits Chromosome 6, band 6p21.33 — between genes, 0.2 kb from TNF.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Crohn's disease compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Crohn's disease.

G/G Published research associates this genotype with typical/baseline likelihood of Crohn's disease — no copies of the reported risk allele.

Source

Sex-Dimorphic Analyses Identify Novel and Sex-Specific Genetic Associations in Inflammatory Bowel Disease

Khrom M, Li D, Naito T, Lee HS, Botwin GJ, Potdar AA, Boucher G, Yang S, Mengesha E, Dube S, Song K, McGovern DPB

and 1 more — show all

Haritunians T

NIDDK Inflammatory Bowel Disease Genetics Consortium · International Inflammatory Bowel Disease Genetics Consortium

Inflammatory bowel diseases · 2023 · PMID 37262302

Questions about rs361525

What is rs361525?

rs361525 is a single position in the genome, in or near the near TNF gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs361525 linked to?

On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs361525 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs361525 come from?

GWAS Catalog, Inflammatory bowel diseases 2023, PMID:37262302. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Crohn's disease (rs361525). MyGeneLog™. https://www.mygenelog.com/variants/rs361525

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