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Who was studied 507,850 East Asian ancestry individuals, 420,829 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0136 lower (95% confidence interval 0.01-0.017); p = 7 × 10−17.
Where it sits Chromosome 1, band 1p35.2 — in an intron of ZCCHC17.
What each result means
A/ATwo copies of the version the research linked to Creatinine levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Creatinine levels. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Creatinine levels. This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 40436827 · open access
Questions about rs35998242
What is rs35998242?
rs35998242 is a single position in the genome, in or near the FABP3 gene. Published research associates it with creatinine levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs35998242 linked to?
On MyGeneLog this position is linked to Kidney Function. The research behind each link, and its sources, are set out on that condition page.
Does having rs35998242 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs35998242 come from?
GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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