Anti-SARS-CoV-2 spike protein IgG seronegativity after first dose of COVID-19 vaccine
HLA-DQB1 · rs35986240
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 37,229 European ancestry cases, 16,837 European ancestry controls.
The effect
The reported allele is A; the catalogue records no effect size
; p = 5 × 10−10.
How common The A allele had a frequency of about 3% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — in an intron of HLA-DQB1.
What each result means
A/ATwo copies of the version the research linked to Anti-SARS-CoV-2 spike protein IgG seronegativity after first dose of COVID-19 vaccine. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Anti-SARS-CoV-2 spike protein IgG seronegativity after first dose of COVID-19 vaccine. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Anti-SARS-CoV-2 spike protein IgG seronegativity after first dose of COVID-19 vaccine. This is the starting point the study compared everyone against.
American journal of human genetics · 2024 · PMID 38181733 · open access
Questions about rs35986240
What is rs35986240?
rs35986240 is a single position in the genome, in or near the HLA-DQB1 gene. Published research associates it with anti-sars-cov-2 spike protein igg seronegativity after first dose of covid-19 vaccine. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs35986240 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs35986240 come from?
GWAS Catalog, American journal of human genetics 2024, PMID:38181733. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Anti-SARS-CoV-2 spike protein IgG seronegativity after first dose of COVID-19 vaccine (rs35986240). MyGeneLog™. https://www.mygenelog.com/variants/rs35986240