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Who was studied 6,333 European ancestry cases, 15,056 European ancestry controls; replicated in 15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry trios.
The effect
Each copy of the T allele carried 1.08 times the odds of Crohn's disease (95% confidence interval 1.04-1.12); p = 3 × 10−12.
How common The T allele had a frequency of about 57% in the people studied.
Where it sits Chromosome 5, band 5q35.2 — between genes, 35.5 kb from CPEB4.
What each result means
C/CNo copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs359457 is a single position in the genome, in or near the CPEB4 gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs359457 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs359457 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs359457 come from?
GWAS Catalog, Nat Genet 2010, PMID:21102463. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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