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Urinary magnesium-to-creatinine ratio

ARL15 · rs35929

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied up to 5,810 European ancestry individuals, up to 1,541 Val Borbera (founder/genetic isolate) individuals, up to 281 Carlantino (founder/genetic isolate) individuals, up to 889 Korcula (founder/genetic isolate) individuals, up to 489 Split (founder/genetic isolate) individuals, up to 195 Vis (founder/genetic isolate) individuals.

The effect Each copy of the A allele shifted the measure 0.123 lower (95% confidence interval -0.23598-0.48138); p = 2 × 10−11.

How common The A allele had a frequency of about 21% in the people studied.

Where it sits Chromosome 5, band 5q11.2 — in an intron of ARL15.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Urinary magnesium-to-creatinine ratio compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Urinary magnesium-to-creatinine ratio.
G/G Published research associates this genotype with typical/baseline likelihood of Urinary magnesium-to-creatinine ratio — no copies of the reported risk allele.
Source
Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes
Corre T, Arjona FJ, Hayward C, Youhanna S, de Baaij JHF, Belge H, Nägele N, Debaix H, Blanchard MG, Traglia M, Harris SE, Ulivi S
and 29 more — show all
Rueedi R, Lamparter D, Macé A, Sala C, Lenarduzzi S, Ponte B, Pruijm M, Ackermann D, Ehret G, Baptista D, Polasek O, Rudan I, Hurd TW, Hastie ND, Vitart V, Waeber G, Kutalik Z, Bergmann S, Vargas-Poussou R, Konrad M, Gasparini P, Deary IJ, Starr JM, Toniolo D, Vollenweider P, Hoenderop JGJ, Bindels RJM, Bochud M, Devuyst O
Journal of the American Society of Nephrology : JASN · 2018 · PMID 29093028

Questions about rs35929

What is rs35929?

rs35929 is a single position in the genome, in or near the ARL15 gene. Published research associates it with urinary magnesium-to-creatinine ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs35929 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35929 come from?

GWAS Catalog, J Am Soc Nephrol 2017, PMID:29093028. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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