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Self-reported risk-taking behaviour

PRIMA1 · rs35914833

What the study found

Who was studied 113,882 European ancestry cases, 322,354 European ancestry controls.

The effect Each copy of the T allele carried 1.02 times the odds of Self-reported risk-taking behaviour (95% confidence interval 1.015-1.033); p = 5 × 10−8.

How common The T allele had a frequency of about 68% in the people studied.

Where it sits Chromosome 14, band 14q32.12 — between genes, 2.3 kb from PRIMA1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Self-reported risk-taking behaviour — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Self-reported risk-taking behaviour.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Self-reported risk-taking behaviour compared to the general population.
Source

Questions about rs35914833

What is rs35914833?

rs35914833 is a single position in the genome, in or near the PRIMA1 gene. Published research associates it with self-reported risk-taking behaviour. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs35914833 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35914833 come from?

GWAS Catalog, Commun Biol 2018, PMID:30271922. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Self-reported risk-taking behaviour (rs35914833). MyGeneLog™. https://www.mygenelog.com/variants/rs35914833

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