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Body fat distribution (trunk fat ratio)

SMAD3 · rs35874463

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Body fat distribution (trunk fat ratio) — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body fat distribution (trunk fat ratio).

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body fat distribution (trunk fat ratio) compared to the general population.

Source

Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects

Rask-Andersen M, Karlsson T, Ek WE, Johansson Å

Nature communications · 2019 · PMID 30664634 · open access

Questions about rs35874463

What is rs35874463?

rs35874463 is a single position in the genome, in or near the SMAD3 gene. Published research associates it with body fat distribution (trunk fat ratio). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs35874463 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35874463 come from?

GWAS Catalog, Nat Commun 2019, PMID:30664634. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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