Cardiovascular delta age (difference between ECG-predicted and chronological age)
SIPA1L1 · rs35866366
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 31,475 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.29 higher (95% confidence interval 0.21-0.37); p = 3 × 10−12.
How common The G allele had a frequency of about 24% in the people studied.
Where it sits Chromosome 14, band 14q24.2 — in an intron of SIPA1L1.
What each result means
A/ANo copy of the version the research linked to Cardiovascular delta age (difference between ECG-predicted and chronological age). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Cardiovascular delta age (difference between ECG-predicted and chronological age). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Cardiovascular delta age (difference between ECG-predicted and chronological age). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2023 · PMID 37604819 · open access
Questions about rs35866366
What is rs35866366?
rs35866366 is a single position in the genome, in or near the SIPA1L1 gene. Published research associates it with cardiovascular delta age (difference between ecg-predicted and chronological age). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs35866366 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs35866366 come from?
GWAS Catalog, Nature communications 2023, PMID:37604819. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Cardiovascular delta age (difference between ECG-predicted and chronological age) (rs35866366). MyGeneLog™. https://www.mygenelog.com/variants/rs35866366