Retinal thickness (functional principal component 6)
near MYO1H · rs35845043
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 43,153 European ancestry individuals; replicated in 1,179 Central or South Asian individuals, 1,161 African ancestry individuals.
The effect
Each copy of the T allele shifted the measure 14.7 higher (95% confidence interval 10.44-18.96); p = 1 × 10−11.
How common The T allele had a frequency of about 20% in the people studied.
Where it sits Chromosome 12, band 12q24.11 — between genes, 17 kb from MYO1H.
What each result means
G/GNo copy of the version the research linked to Retinal thickness (functional principal component 6). This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Retinal thickness (functional principal component 6). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Retinal thickness (functional principal component 6). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2025 · PMID 39904976 · open access
Questions about rs35845043
What is rs35845043?
rs35845043 is a single position in the genome, in or near the near MYO1H gene. Published research associates it with retinal thickness (functional principal component 6). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs35845043 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs35845043 come from?
GWAS Catalog, Nature communications 2025, PMID:39904976. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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Retinal thickness (functional principal component 6) (rs35845043). MyGeneLog™. https://www.mygenelog.com/variants/rs35845043