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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.00993 lower (95% confidence interval 0.0074-0.0124); p = 3 × 10−17.
How common The G allele had a frequency of about 45% in the people studied.
Where it sits Chromosome 9, band 9q33.3 — in an intron of HSPA5-DT.
What each result means
G/GTwo copies of the version the research linked to Basal metabolic rate (UKB data field 23105). That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Basal metabolic rate (UKB data field 23105). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Basal metabolic rate (UKB data field 23105). This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs35843221
What is rs35843221?
rs35843221 is a single position in the genome, in or near the HSPA5-DT gene. Published research associates it with basal metabolic rate (ukb data field 23105). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs35843221 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs35843221 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs35843221 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Basal metabolic rate (UKB data field 23105) (rs35843221). MyGeneLog™. https://www.mygenelog.com/variants/rs35843221