Gene Knowledge Graph
UTC
Standard

Remission after SSRI treatment in MDD or neuroticism

XKR6 · rs35792458

Where this position leads

Condition: Neuroticism

rs35792458 Condition: Neuroticism Neuroticism Condition rs35792458 rs35792458 XKR6

What the study found

Who was studied 865 individuals with SSRI response data, 170,911 individuals with personality trait data.

The effect The reported allele is C; the catalogue records no effect size ; p = 1 × 10−12.

Where it sits Chromosome 8, band 8p23.1 — in an intron of XKR6.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Remission after SSRI treatment in MDD or neuroticism compared to the general population.
C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Remission after SSRI treatment in MDD or neuroticism.
G/G Published research associates this genotype with typical/baseline likelihood of Remission after SSRI treatment in MDD or neuroticism — no copies of the reported risk allele.
Source
Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder
Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J
and 25 more — show all
Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Kato M, Liu YL, Praphanphoj V, Stingl JC, Bobo WV, Tsai SJ, Kubo M, Klein TE, Weinshilboum RM, Biernacka JM, Baune BT
Frontiers in psychiatry · 2018 · PMID 29559929 · open access

Questions about rs35792458

What is rs35792458?

rs35792458 is a single position in the genome, in or near the XKR6 gene. Published research associates it with remission after ssri treatment in mdd or neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs35792458 linked to?

On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.

Does having rs35792458 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35792458 come from?

GWAS Catalog, Front Psychiatry 2018, PMID:29559929. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

← See all variants