Standard

Urolithiasis

PDILT · rs35747824

Where this position leads

What the study found

Who was studied 11,130 Japanese ancestry cases, 187,639 Japanese ancestry controls; replicated in 2,289 Japanese ancestry cases, 3,817 Japanese ancestry controls.

The effect Each copy of the T allele carried 1.11 times the odds of Urolithiasis; p = 9 × 10⁻¹¹.

How common The T allele had a frequency of about 22% in the people studied.

Where it sits Chromosome 16, band 16p12.3 — in an intron of PDILT.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Urolithiasis — no copies of the reported risk allele.

A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Urolithiasis.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Urolithiasis compared to the general population.

Source

Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese Population

Tanikawa C, Kamatani Y, Terao C, Usami M, Takahashi A, Momozawa Y, Suzuki K, Ogishima S, Shimizu A, Satoh M, Matsuo K, Mikami H

and 12 more — show all

Naito M, Wakai K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Kohri K, Yu ASL, Yasui T, Murakami Y, Kubo M, Matsuda K

Journal of the American Society of Nephrology : JASN · 2019 · PMID 30975718

In the news

2026-01-28 · Namba S, et al., Nature 2026, PMID:41606330

A cross-population compendium of gene-environment interactions

An atlas of gene-environment interactions — where a variant's effect size differs by age, sex or lifestyle — built from 440,210 people of European and Japanese ancestry and replicated in 539,794 more from diverse populations. Decomposing the contributions of age, sex and lifestyle exposed the aetiology of these interactions, including reverse causality from disease-driven changes in diet, and showed that they affect polygenic prediction accuracy and how well scores transfer across populations. Omics-level analyses found sex-discordant genetic effects in lipid metabolism, which the authors connect to failures of genetically supported drug trials. The variant that dominates this catalogue's overlap with the study is rs671 in ALDH2 — the alcohol flush variant — whose effects on liver enzymes (AST, ALT), HDL cholesterol and red-cell indices differ by sex, ever-drinking and smoking; also on this site from the study: rs145954970 (SLC22A11, uric acid, gout), rs11066015 (ACAD10, red-cell count by drinking), rs730154 (CYP19A1, height by sex) and rs35747824 (PDILT, creatinine by age). PMID:41606330.

Questions about rs35747824

What is rs35747824?

rs35747824 is a single position in the genome, in or near the PDILT gene. Published research associates it with urolithiasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs35747824 linked to?

On MyGeneLog this position is linked to Urolithiasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs35747824 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35747824 come from?

GWAS Catalog, J Am Soc Nephrol 2019, PMID:30975718. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Urolithiasis (rs35747824). MyGeneLog™. https://www.mygenelog.com/variants/rs35747824

← See all variants