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Weight

ARHGEF26 · rs357475

Where this position leads

Condition: Obesity and Body Weight

rs357475 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs357475 rs357475 ARHGEF26

What the study found

Who was studied 507,850 East Asian ancestry individuals, 420,829 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0135 lower (95% confidence interval 0.011-0.016); p = 2 × 10−20.

Where it sits Chromosome 3, band 3q25.2 — in an intron of ARHGEF26.

What each result means

A/A Two copies of the version the research linked to Weight. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Weight. That is a smaller link than two copies.
C/C No copy of the version the research linked to Weight. This is the starting point the study compared everyone against.
Source

Questions about rs357475

What is rs357475?

rs357475 is a single position in the genome, in or near the ARHGEF26 gene. Published research associates it with weight. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs357475 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs357475 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs357475 come from?

GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Weight (rs357475). MyGeneLog™. https://www.mygenelog.com/variants/rs357475

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