Standard
Fasting blood insulin
IGF1 · rs35747
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied Up to 51,750 European ancestry individuals; replicated in Up to 33,823 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0233 higher (95% confidence interval 0.015-0.031); p = 9 × 10−9.
How common The A allele had a frequency of about 82% in the people studied.
Where it sits Chromosome 12, band 12q23.2 — in an intron of LINC02456.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Fasting blood insulin compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Fasting blood insulin.
G/G
Published research associates this genotype with typical/baseline likelihood of Fasting blood insulin — no copies of the reported risk allele.
Source
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
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and 204 more — show all
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Nature genetics · 2012 · PMID 22581228
Questions about rs35747
What is rs35747?
rs35747 is a single position in the genome, in or near the IGF1 gene. Published research associates it with fasting blood insulin. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs35747 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs35747 come from?
GWAS Catalog, Nat Genet 2012, PMID:22581228. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants