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Body mass index or knee osteoarthritis (pleiotropy)

WSCD2 · rs35739367

Where this position leads

Condition: Knee Osteoarthritis

rs35739367 Condition: Knee Osteoarthritis Knee Osteoarthritis Condition rs35739367 rs35739367 WSCD2

What the study found

Who was studied 806,834 European ancestry BMI individuals, 62,497 European ancestry knee osteoarthritis cases, 333,557 European ancestry controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 8 × 10−11.

Where it sits Chromosome 12, band 12q23.3 — in an intron of WSCD2.

What each result means

A/A Two copies of the version the research linked to Body mass index or knee osteoarthritis (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Body mass index or knee osteoarthritis (pleiotropy). That is a smaller link than two copies.
G/G No copy of the version the research linked to Body mass index or knee osteoarthritis (pleiotropy). This is the starting point the study compared everyone against.
Source
A sex- and site-specific relationship between body mass index and osteoarthritis: evidence from observational and genetic analyses
Zhang L, Zhang W, Wu X, Cui H, Yan P, Yang C, Zhao X, Xiao J, Xiao C, Tang M, Wang Y, Chen L
and 10 more — show all
Liu Y, Zou Y, Zhang L, Yang Y, Yao Y, Li J, Liu Z, Yang C, Zhang B, Jiang X
Osteoarthritis and cartilage · 2023 · PMID 36889626

Questions about rs35739367

What is rs35739367?

rs35739367 is a single position in the genome, in or near the WSCD2 gene. Published research associates it with body mass index or knee osteoarthritis (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs35739367 linked to?

On MyGeneLog this position is linked to Knee Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs35739367 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35739367 come from?

GWAS Catalog, Osteoarthritis and cartilage 2023, PMID:36889626. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Body mass index or knee osteoarthritis (pleiotropy) (rs35739367). MyGeneLog™. https://www.mygenelog.com/variants/rs35739367

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