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X-11308 levels

ACOT4 · rs35724886

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 14,296 European ancestry individuals; replicated in 5,698 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.164 higher (95% confidence interval 0.14-0.19); p = 7 × 10−36.

How common The A allele had a frequency of about 21% in the people studied.

Where it sits Chromosome 14, band 14q24.3 — a missense change in ACOT4.

What ClinVar records

Classification Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2024-08-30. ClinVar record 2798877 NM_152331.4(ACOT4):c.560C>A (p.Ala187Asp)

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to X-11308 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to X-11308 levels. That is a smaller link than two copies.
C/C No copy of the version the research linked to X-11308 levels. This is the starting point the study compared everyone against.
Source
Rare and common genetic determinants of metabolic individuality and their effects on human health
Surendran P, Stewart ID, Au Yeung VPW, Pietzner M, Raffler J, Wörheide MA, Li C, Smith RF, Wittemans LBL, Bomba L, Menni C, Zierer J
and 24 more — show all
Rossi N, Sheridan PA, Watkins NA, Mangino M, Hysi PG, Di Angelantonio E, Falchi M, Spector TD, Soranzo N, Michelotti GA, Arlt W, Lotta LA, Denaxas S, Hemingway H, Gamazon ER, Howson JMM, Wood AM, Danesh J, Wareham NJ, Kastenmüller G, Fauman EB, Suhre K, Butterworth AS, Langenberg C
Nature medicine · 2022 · PMID 36357675 · open access

Questions about rs35724886

What is rs35724886?

rs35724886 is a single position in the genome, in or near the ACOT4 gene. Published research associates it with x-11308 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs35724886 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35724886 come from?

GWAS Catalog, Nature medicine 2022, PMID:36357675. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

X-11308 levels (rs35724886). MyGeneLog™. https://www.mygenelog.com/variants/rs35724886

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