Gene Knowledge Graph
UTC
Standard

Phospholipids to Total Lipids in Very Small VLDL percentage

near MC4R · rs35693910

Where this position leads

Conditions: Cholesterol (LDL, HDL and Total), Osteoarthritis

rs35693910 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition Condition: Osteoarthritis Osteoarthritis Condition rs35693910 rs35693910 near MC4R

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the A allele shifted the measure 0.02 % higher (95% confidence interval 0.02-0.02); p = 2 × 10−21.

Where it sits Chromosome 18, band 18q21.32 — between genes, 83 kb from RNU4-17P.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Phospholipids to Total Lipids in Very Small VLDL percentage compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Phospholipids to Total Lipids in Very Small VLDL percentage.
G/G Published research associates this genotype with typical/baseline likelihood of Phospholipids to Total Lipids in Very Small VLDL percentage — no copies of the reported risk allele.
Source
A genetic map of human metabolism across the allele frequency spectrum
Zoodsma M, Beuchel C, Yasmeen S, Kohleick L, Nepal A, Koprulu M, Kronenberg F, Mayr M, Williamson A, Pietzner M, Langenberg C
Nature genetics · 2025 · PMID 41044249 · open access

Questions about rs35693910

What is rs35693910?

rs35693910 is a single position in the genome, in or near the near MC4R gene. Published research associates it with phospholipids to total lipids in very small vldl percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs35693910 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total), Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs35693910 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35693910 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Phospholipids to Total Lipids in Very Small VLDL percentage (rs35693910). MyGeneLog™. https://www.mygenelog.com/variants/rs35693910

← See all variants