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Suicidal thoughts and behaviors

FBXL19 · rs35675346

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 75,941 European ancestry cases, 376,826 European ancestry controls, 30,283 African ancestry cases, 90,835 African ancestry controls, 13,230 Hispanic cases, 38,378 Hispanic controls, 1,757 Asian ancestry cases, 6,528 Asian ancestry controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 3 × 10−10.

How common The A allele had a frequency of about 25% in the people studied.

Where it sits Chromosome 16, band 16p11.2 — in an intron of FBXL19.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Suicidal thoughts and behaviors compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Suicidal thoughts and behaviors.
G/G Published research associates this genotype with typical/baseline likelihood of Suicidal thoughts and behaviors — no copies of the reported risk allele.
Source
Identification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans
Kimbrel NA, Ashley-Koch AE, Qin XJ, Lindquist JH, Garrett ME, Dennis MF, Hair LP, Huffman JE, Jacobson DA, Madduri RK, Trafton JA, Coon H
and 9 more — show all
Docherty AR, Mullins N, Ruderfer DM, Harvey PD, McMahon BH, Oslin DW, Beckham JC, Hauser ER, Hauser MA
Million Veteran Program Suicide Exemplar Workgroup, the International Suicide Genetics Consortium, the Veterans Affairs Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, and the Veterans Affairs Million Veteran Program
JAMA psychiatry · 2023 · PMID 36515925

Questions about rs35675346

What is rs35675346?

rs35675346 is a single position in the genome, in or near the FBXL19 gene. Published research associates it with suicidal thoughts and behaviors. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs35675346 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35675346 come from?

GWAS Catalog, JAMA psychiatry 2023, PMID:36515925. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Suicidal thoughts and behaviors (rs35675346). MyGeneLog™. https://www.mygenelog.com/variants/rs35675346

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