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LRRN1 protein levels

SUMF1 · rs35596257

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.548 higher (95% confidence interval 0.46-0.64); p = 6 × 10−38.

How common The A allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 3, band 3p26.2 — inside SUMF1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of LRRN1 protein levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with LRRN1 protein levels.
G/G Published research associates this genotype with typical/baseline likelihood of LRRN1 protein levels — no copies of the reported risk allele.
Source

Questions about rs35596257

What is rs35596257?

rs35596257 is a single position in the genome, in or near the SUMF1 gene. Published research associates it with lrrn1 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs35596257 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35596257 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

LRRN1 protein levels (rs35596257). MyGeneLog™. https://www.mygenelog.com/variants/rs35596257

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