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IgG monogalactosylation phenotypes (multivariate analysis)

IGH · rs35590487

What the study found

Who was studied 1,960 Orcadian (founder/genetic isolate) individuals.

The effect The reported allele is T; the catalogue records no effect size ; p = 4 × 10−17.

How common The T allele had a frequency of about 23% in the people studied.

Where it sits Chromosome 14, band 14q32.33 — between genes, 2.7 kb from TMEM121.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of IgG monogalactosylation phenotypes (multivariate analysis) — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with IgG monogalactosylation phenotypes (multivariate analysis).
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of IgG monogalactosylation phenotypes (multivariate analysis) compared to the general population.
Source

Questions about rs35590487

What is rs35590487?

rs35590487 is a single position in the genome, in or near the IGH gene. Published research associates it with igg monogalactosylation phenotypes (multivariate analysis). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs35590487 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35590487 come from?

GWAS Catalog, Nat Commun 2017, PMID:28878392. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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IgG monogalactosylation phenotypes (multivariate analysis) (rs35590487). MyGeneLog™. https://www.mygenelog.com/variants/rs35590487

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