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Body mass index

DHX36 · rs355777

Where this position leads

What the study found

Who was studied 374,756 European ancestry male individuals.

The effect Each copy of the C allele shifted the measure 0.0151 higher (95% confidence interval 0.012-0.018); p = 2 × 10⁻¹⁸.

How common The C allele had a frequency of about 40% in the people studied.

Where it sits Chromosome 3, band 3q25.2 — in an intron of DHX36.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body mass index compared to the general population.

C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body mass index.

G/G Published research associates this genotype with typical/baseline likelihood of Body mass index — no copies of the reported risk allele.

Source

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry

Pulit SL, Stoneman C, Morris AP, Wood AR, Glastonbury CA, Tyrrell J, Yengo L, Ferreira T, Marouli E, Ji Y, Yang J, Jones S

and 10 more — show all

Beaumont R, Croteau-Chonka DC, Winkler TW, Hattersley AT, Loos RJF, Hirschhorn JN, Visscher PM, Frayling TM, Yaghootkar H, Lindgren CM

GIANT Consortium

Human molecular genetics · 2019 · PMID 30239722 · open access

Questions about rs355777

What is rs355777?

rs355777 is a single position in the genome, in or near the DHX36 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs355777 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs355777 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs355777 come from?

GWAS Catalog, Hum Mol Genet 2018, PMID:30239722. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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