Sensitive

Rheumatoid arthritis

RTKN2 · rs35576264

Where this position leads

Condition: Rheumatoid Arthritis

rs35576264 Condition: Rheumatoid Arthritis Rheumatoid Arthritis Condition rs35576264 rs35576264 RTKN2

What the study found

Who was studied 14,361 European ancestry cases, 43,923 European ancestry controls, 8,267 East Asian ancestry cases, 244,741 East Asian ancestry controls.

The effect Each copy of the T allele shifted the measure 0.103 higher (95% confidence interval 0.068-0.138); p = 9 × 10−9.

Where it sits Chromosome 10, band 10q21.2 — in an intron of RTKN2.

What each result means

C/C No copy of the version the research linked to Rheumatoid arthritis. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Rheumatoid arthritis. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Rheumatoid arthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs35576264

What is rs35576264?

rs35576264 is a single position in the genome, in or near the RTKN2 gene. Published research associates it with rheumatoid arthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs35576264 linked to?

On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs35576264 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35576264 come from?

GWAS Catalog, Annals of the rheumatic diseases 2021, PMID:33310728. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Rheumatoid arthritis (rs35576264). MyGeneLog™. https://www.mygenelog.com/variants/rs35576264

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